Open Adobe Photoshop and then open the photo you would like to use. File -> Open -> select a picture you want -> Open.
For example in this tutorial I chose a picture of a well known character. If you haven't recognized him yet, it is Indiana Jones. On the left you can see how the image looked before I applyed any effects.
2. Setting the Treshold
Now the colors of the photo have to be replaced by only two colors. One way to do that, and is to use "treshold" effect. To do that go to Image -> Adjustments -> Treshold.. and you will see the window od the treshold effect. There you can slide the pointer left or right to get the effect you want. On the three pictures below you can see how the picture changes when the value of the treshold rises. For this photo I chose the value of 153, which was just where the whole background dissapeared but enough of the face remained. You can see that in the middle picture.
3. Resizing the Canvas
Resize canvas to make room for different copies of the picture by clicking on Image -> Canvas Size.. and setting the parameters the way you want. In this example I chose to have 4 variations of the picture, so I set the Width and Height of the canvas to 200 percent and anchored it to the top left corner, so it would be easier later to copy and paste the picture. All settings can be seen on the left picture.
On those two pictures you can see how the canvas resized four times after I applyed the effect and the picture stayed on the top left corner.
4. Multiplying the Picture
To make four copies of the picture select the picture with the Rectangular Marquee Tool, click on Edit -> Copy and than Edit -> Paste. The copied picture will appear on top of the original but in a new layer. Move it to the right with the Move Tool. Repeat the process two more times to get 4 copies of the picture.
Rectangular Marquee Tool
Move Tool
On these four pictures you can see the copying process.
5. Coloring the pictures
Now comes the most fun part of the process. Asign any color you want to each copy of the picture. You can do that by using the Paint Bucket Tool. When you click on that tool you will see it's options above. Make sure the Contiguous option is unchecked. That way you can color all of the same colored area of a layer with one click. You can choose to color only the white parts or only the black parts or both (see the exmamples at the end of this tutorials)
Paint Bucket Tool
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Note that every picture is still in it's own layer so when coloring you each time have to select a different layer. For example on the picture below the top right picture was on Layer 1 so when coloring it I selected Layer 1. If you don't have the Layer window open you can do that by clicking on Window -> Layers.
6. Flattening and Saving
When you are finished with coloring you will probably want to save the picture. I usually flatten the image before saving. You can do that by clicking on Layer -> Flatten Image. Then save by File -> Save As -> choose a name and format (I saved it as .jpg).
On the left is the finished image of my example. Here just the white parts were colored. Below you can see some more examples, where I also colored the black parts. You can also see that in the right picture I made 16 instead of only 4 copies.